Relevant Billing Codes for AmBisome® (amphotericin B) liposome for injection

Proper coding can help facilitate timely claims processing and reduce the risk of denial. Coverage, coding, and reimbursement policies vary by payer, patient, and setting of care. Healthcare providers should verify coverage, coding, and reimbursement guidelines on a case-by-case basis.

 

The coding systems in the following tables can assist you in proper coding for AmBisomea:

Universal 11-digit product identifier for human drugs; each NDC identifies the labeler, product, and trade package size

Code Code Description
00469-3051-30 50-mg single-use vial (amphotericin B) liposome
Notes
Individual vial carton.

Numeric classification descriptive of diseases, injuries, and causes of death, used in hospital outpatient and physician office settings

Code Code Description
B20 Human immunodeficiency virus (HIV) disease
B37.0 Candidal stomatitis
B37.1 Pulmonary candidiasis
B37.41 Candidal cystitis and urethritis
B37.5 Candidal meningitis
B37.6 Candidal endocarditis
B37.7 Candidal sepsis
B37.81 Candidal esophagitis
B37.82 Candidal enteritis
B37.89 Other sites of candidiasis
B37.9 Candidiasis, unspecified
B44.0 Invasive pulmonary aspergillosis
B44.1 Other pulmonary aspergillosis
B44.2 Tonsillar aspergillosis
B44.7 Disseminated aspergillosis
B44.81 Allergic bronchopulmonary aspergillosis
B44.89 Other forms of aspergillosis
B44.9 Aspergillosis, unspecified
B45.0 Pulmonary cryptococcosis
B45.1 Cerebral cryptococcosis
B45.2 Cutaneous cryptococcosis
B45.3 Osseous cryptococcosis
B45.7 Disseminated cryptococcosis
B45.8 Other forms of cryptococcosis
B45.9 Cryptococcosis, unspecified
B55.0 Visceral leishmaniasis
B97.35 HIV 2 as the cause of diseases classified elsewhere
D70.0 Congenital agranulocytosis
D70.1 Agranulocytosis secondary to cancer chemotherapy
D70.2 Other drug-induced agranulocytosis
D70.3 Neutropenia due to infection
D70.4 Cyclic neutropenia
D70.8 Other neutropenia
D70.9 Neutropenia, unspecified
G02 Meningitis in other infectious and parasitic diseases classified elsewhere
G03.0 Nonpyogenic meningitis
G03.1 Chronic meningitis
G03.8 Meningitis due to other specified causes
G03.9 Meningitis, unspecified
H44.19 Other endophthalmitis
I30.0 Acute nonspecific idiopathic pericarditis
I30.1 Infective pericarditis
I30.8 Other forms of acute pericarditis
I30.9 Acute pericarditis, unspecified
I32 Pericarditis in diseases classified elsewhere
I33.0 Acute and subacute infective endocarditis
I33.9 Acute and subacute endocarditis, unspecified
I38 Endocarditis, valve unspecified
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
I40.0 Infective myocarditis
I40.8 Other acute myocarditis
I40.9 Acute myocarditis, unspecified
I41 Myocarditis in diseases classified elsewhere
R50.81 Fever presenting with conditions classified elsewhere
R50.82 Postprocedural fever
R50.9 Fever, unspecified
R68.0 Hypothermia, not associated with low environmental temperature
R68.83 Chills (without fever)
R75 Inconclusive laboratory evidence of human immunodeficiency virus [HIV]
Z21 Asymptomatic human immunodeficiency virus [HIV] infection status

Numeric classification descriptive of procedures performed in hospital inpatient setting 

Code Code Description
3E03029 Introduction of Other Anti-infective into Peripheral Vein, Open Approach
3E03329 Introduction of Other Anti-infective into Peripheral Vein, Percutaneous Approach 
3E04029 Introduction of Other Anti-infective into Central Vein, Open Approach
3E04329 Introduction of Other Anti-infective into Central Vein, Percutaneous Approach
Notes
Assign the appropriate code for the service provided.

4-digit codes that all hospitals use to capture cost data by department

Code Code Description
0250 Pharmacy-General
0260 IV Therapy-General
0636 Pharmacy-Extension (drugs requiring detailed coding)
Notes
Some payers, such as Medicare, require certain combinations of revenue codes and Healthcare Common Procedure Coding System (HCPCS) or CPT®b codes to facilitate claims processing. Confirm requirements with local payer policies.

5-digit codes that describe procedures and services performed by physicians and other healthcare providers

Code Code Description
96365 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour 
96366 Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (list separately in addition to code for primary procedure)
Notes
Select appropriate codes based on length of infusion.

aIMPORTANT INFORMATION: The coding, coverage, and payment information contained herein is gathered from various resources, general in nature, and subject to change without notice. Third-party payment for medical products and services is affected by numerous factors. It is always the provider's responsibility to determine the appropriate healthcare setting and to submit true and correct claims conforming to the requirements of the relevant payer for those products and services rendered. Pharmacies (or any other provider submitting a claim) should contact third-party payers for specific information on their coding, coverage, and payment policies. Information and materials provided by AmBisome Support Solutions are to assist providers and pharmacies, but the responsibility to determine coverage, reimbursement, and appropriate coding for a particular patient and/or procedure remains at all times with the provider and pharmacy, and information provided by AmBisome Support Solutions or Astellas should in no way be considered a guarantee of coverage or reimbursement for any product or service.

bAmerican Medical Association. Current Procedural Terminology® (CPT®). Professional edition, 2023. All rights reserved. Applicable FARS/DFARS Restrictions Apply to Government Use. Fee schedules, relative value units, conversion factors and/or related components are not assigned by the AMA, are not part of CPT®, and the AMA is not recommending their use. The AMA does not directly or indirectly practice medicine or dispense medical services. The AMA assumes no liability for data contained or not contained herein.

References: 1. AmBisome [package insert]. Northbrook, IL: Astellas Pharma US, Inc. 2. Centers for Medicare and Medicaid Services. ICD-10-CM tabular list of diseases and injuries. Updated August 7, 2025. Accessed August 14, 2025. https://www.cms.gov/medicare/coding-billing/icd-10-codes 3. 2025 ICD-10-PCS Codes. ICD10Data.com. Accessed August 6, 2025. https://www.icd10data.com/ICD10PCS/codes 4. Noridian Healthcare Solutions. Jurisdiction E - Medicare Part A: revenue codes. Updated June 17, 2025. Accessed August 7, 2025. https://med.noridianmedicare.com/web/jea/topics/claim-submission/revenue-codes 5. American Medical Association. CPT® 2024 Professional Edition. American Medical Association, 2023.

AmBisome® is a registered trademark of Gilead Sciences, Inc.