Support for Your PADCEV Patients

PADCEV Support SolutionsSM, a component of Astellas Pharma Support SolutionsSM, offers access and reimbursement support to help patients access PADCEV® (enfortumab vedotin-ejfv).

 

PADCEV Support Solutions provides information regarding patient healthcare coverage, financial assistance information that may be available to help patients with financial needs, and coding and billing information for PADCEV.

 

To speak with a dedicated access specialist, please call us at 1-888-402-0627, Monday–Friday, 8:30 AM–8:00 PM ET.

After the patient has been prescribed PADCEV, the patient can be enrolled in PADCEV Support Solutions.a

There Are 3 Ways to Enroll Your Patient 

  1. Complete and print out the Patient Enrollment Form, including the patient's and healthcare provider's signatures, and fax to 1-877-747-6843.
  2. Log into the Prescriber Portal to enroll the patient online by completing the Patient Enrollment Form. 
  3. Contact PADCEV Support Solutions to enroll over the phone by calling 1-888-402-0627, Monday–Friday, 8:30 AM–8:00 PM ET.

PADCEV Support Solutionsa offers benefits investigation assistance to evaluate a patient's insurance coverageb for PADCEV. After performing a benefits investigation, we will provide a Summary of Benefits that includes:

 

  • The patient's insurance coverage for PADCEV
  • Requirements for prior authorization or other coverage restrictions, if any
  • Cost-sharing responsibilities, including the deductible, coinsurance or copayment, and out-of-pocket maximums

The Process

  1. PADCEV Support Solutions will initiate a benefits investigation upon receipt of a completed patient enrollment form.
  2. When the benefits investigation is complete, PADCEV Support Solutions will provide a Summary of Benefits.

PADCEV Support Solutionsa can provide prior authorization (PA) assistance when a patient's insurer requires PA approval.

The Process

  1. After determining that a PA is required, PADCEV Support Solutions will obtain the appropriate PA form.
  2. PADCEV Support Solutions will transfer solely basic patient and healthcare provider demographic information to the required PA form and send it to the healthcare provider to review, complete, and sign.c
  3. PADCEV Support Solutions will inform the healthcare provider how and where to submit the completed PA form to the insurer. 
  4. PADCEV Support Solutions will follow up with the insurer to confirm receipt and check status.

Prior Authorization Denial Appeals

If the patient's insurer denies a PA request and the healthcare provider determines that an appeal is appropriate, PADCEV Support Solutions can assist the healthcare provider with the appeal process for a denied PA request.

 

  1. PADCEV Support Solutions will determine if any additional documentation is required by the patient's insurer.
  2. PADCEV Support Solutions will inform the healthcare provider of what information is needed and where to send the appeal.c
  3. The healthcare provider completes and submits the appeal to the insurer.
  4. PADCEV Support Solutions will track and inform the healthcare provider of the appeal status.

Relevant Billing Codes for PADCEV

Properly coding claims can help facilitate timely claims processing and reduce the risk of denied claims. Coverage, coding, and reimbursement policies vary by payer, patient, and setting of care. Healthcare providers should verify coverage, coding, and reimbursement guidelines on a case-by-case basis.

 

The PADCEV Billing and Coding Guide is a downloadable resource for your office. In addition, the coding systems in the tables below can assist you in proper coding for PADCEV.d

5-digit alphanumeric code

HCPCS Code Description Billing Unit Payer and Settings of Care
J9177 Injection, enfortumab vedotin-ejfv, 0.25 mg 0.25 mg = 1 billing unit Most payers (eg, commercial, Medicare, and Medicaid) and care settings (eg, hospital outpatient and physician office)

1 billing unit of J9177 equals 0.25 mg of enfortumab vedotin-ejfv.1 As a result, 80 units equals 1 single-dose 20-mg vial and 120 units equals 1 single-dose 30-mg vial. Actual units reported will vary by dosage required for each individual patient. 

Universal 11-digit product identifier for human drugs; each NDC identifies the labeler, product, and trade package size

NDC Code Code Description
51144-0020-01 20 mg lyophilized powder in a single-dose vial for reconstitution
51144-0030-01 30 mg lyophilized powder in a single-dose vial for reconstitution

5-digit codes that describe procedures and services performed by physicians and other healthcare providers (HCPs)

Code Code Description
96413 Chemotherapy administration, intravenous infusion technique, up to 1 hour, single or initial substance/drug 

Alphanumeric classification descriptive of diseases, injuries, and causes of death

Code Code Description
C65.1 Malignant neoplasm of right renal pelvis
C65.2 Malignant neoplasm of left renal pelvis
C65.9 Malignant neoplasm of unspecified renal pelvis
C66.1 Malignant neoplasm of right ureter
C66.2 Malignant neoplasm of left ureter
C66.9 Malignant neoplasm of unspecified ureter
C67.0 Malignant neoplasm of trigone of bladder
C67.1 Malignant neoplasm of dome of bladder
C67.2 Malignant neoplasm of lateral wall of bladder
C67.3 Malignant neoplasm of anterior wall of bladder
C67.4 Malignant neoplasm of posterior wall of bladder
C67.5 Malignant neoplasm of bladder neck
C67.6 Malignant neoplasm of ureteric orifice
C67.8 Malignant neoplasm of overlapping sites of bladder
C67.9 Malignant neoplasm of bladder, unspecified
C68.0 Malignant neoplasm of urethra
C68.8 Malignant neoplasm of overlapping sites of urinary organs

Patient Assistance

PADCEV Support Solutionsa can provide information about potential programs and patient assistance options that may be available to your PADCEV patients.

The PADCEV Copay Assistance Programf is for eligible patients who have private commercial health insurance and are not insured by any federal or state healthcare program, including, but not limited to, Medicare, Medicaid, TRICARE, or Veterans Affairs (VA). Under this Program:

  • Patients may pay as little as $5 per dose 
  • A patient will be enrolled in the program for a 12-month period 
  • Annual maximum copay assistance limit of $25,000 per calendar year  
  • There are no income requirements 

Enrolling Patients in the PADCEV Copay Assistance Program

PADCEV Support Solutions can evaluate eligibility and enroll patients in the PADCEV Copay Assistance Program. 

 

For more information, contact us at 1-888-402-0627, Monday–Friday, 8:30 AM–8:00 PM ET.

The PADCEV Patient Assistance Programg (PAP) provides PADCEV at no cost to uninsured patients who meet the program eligibility requirements.

Eligibility Requirements

PADCEV Support Solutionsa will evaluate a patient's eligibility for the PAP.

The patient may be eligible for the PAP if he or she:

  • Does not have insurance or has insurance that excludes coverage for PADCEV 
  • Has a verifiable shipping address in the United States 
  • Has been prescribed PADCEV for an FDA-approved indication 
  • Meets the program financial eligibility requirements 

Application Process

Contact PADCEV Support Solutions at 1-888-402-0627 to obtain a copy of the PAP Application. Please fully complete the PAP Application, including all signatures. You can either upload it through the Prescriber Portal or fax it to 1-877-747-6843. If the patient is eligible for the PAP, we will notify you and the patient. 

For more information, contact us at 1-888-402-0627, Monday–Friday, 8:30 AM–8:00 PM ET.

Additional Patient and Caregiver Support

PADCEV Support Solutions, through the Patient Connect program, offers additional patient and caregiver support to patients who have been prescribed PADCEV. This additional support helps connect your patient and their caregivers to educational resources and support based on their particular needs to help them manage their disease and daily life while on treatment. 

 

When a patient or caregiver calls PADCEV Support Solutions, a trained representative will assess their specific needs and will conduct a search of various independent local and national organizationsh that may provide the support and resources requested. 

Patient Connect resources may include:

Emotional Support 

  • Social workers, counseling services, or online communities for patients 
  • Emotional support for the patient's family members and friends 

 

Logistical Support

  • Transportation and lodging assistance related to treatment 
  • Help with other day-to-day tasks 

 

Informational Support

  • Other educational resources about the patient's disease and treatment 
  • Information on nutrition and self-care

 

Patients and their caregivers can call PADCEV Support Solutions at 1-888-402-0627, Monday–Friday, 8:30 AM–8:00 PM ET to learn about potential resources that may be available.

Specialty Distributors for Physicians, Clinics, and Hospitals

PADCEV is a physician-administered drug. Healthcare providers can obtain PADCEV from a participating specialty distributor listed below. 

 

If you need to order PADCEV for your patient or if you have any questions, please contact one of the participating specialty distributors listed below. 

Specialty Distributors for Physicians and Clinics
Distributor  Phone Number 
ASD Healthcare  1-800-746-6273
Cardinal Health Specialty Distribution 1-877-453-3972
McKesson Specialty Health  1-800-482-6700
Oncology Supply 1-800-633-7555
Specialty Distributors for Hospitals
Distributor Phone Number
ASD Healthcare 1-800-746-6273
Cardinal Health Specialty Distribution 1-855-855-0708
McKesson 1-877-625-2566

aPADCEV Support Solutions is a component of Astellas Pharma Support SolutionsSM.

 

bAstellas and Pfizer do not guarantee third-party coverage, payment, or reimbursement for denied claims. Coverage and reimbursement vary by payer, patient, and setting of care and are subject to change. Therefore, it is important that providers verify each patient's insurance coverage prior to initiating therapy. Each healthcare provider is ultimately responsible for determining coverage for individual patients.

 

cThe healthcare provider remains responsible for populating all clinical information.

 

dIMPORTANT INFORMATION: The coding, coverage, and payment information contained herein is gathered from various resources, general in nature, and subject to change without notice. Third-party payment for medical products and services is affected by numerous factors. It is always the provider's responsibility to determine the appropriate healthcare setting and to submit true and correct claims conforming to the requirements of the relevant payer for those products and services rendered. Pharmacies and providers submitting a claim should contact third-party payers for specific information on their coding, coverage, and payment policies. Information and materials provided by PADCEV Support Solutions are to assist pharmacies and other providers submitting a claim, but the responsibility to determine coverage, reimbursement, and appropriate coding for a particular patient and/or procedure remains at all times with the pharmacy and provider that submits the claim. Information provided by PADCEV Support Solutions or Astellas should in no way be considered a guarantee of coverage or reimbursement for any product or service.

 

eAmerican Medical Association. Current Procedural Terminology® (CPT®). Professional edition, 2023. All rights reserved. Applicable FARS/DFARS Restrictions Apply to Government Use. Fee schedules, relative value units, conversion factors and/or related components are not assigned by the AMA, are not part of CPT®, and the AMA is not recommending their use. The AMA does not directly or indirectly practice medicine or dispense medical services. The AMA assumes no liability for data contained or not contained herein.

 

fBy enrolling in the PADCEV Copay Assistance Program ("Program"), the patient acknowledges that they currently meet the eligibility criteria and will comply with the following terms and conditions: The Program is for eligible patients with commercial prescription insurance for PADCEV® (enfortumab vedotin-ejfv) and is good for use only with a valid prescription for PADCEV. The Program has an annual maximum copay assistance limit of $25,000 per calendar year. After the annual maximum on copay assistance is reached, patient will be responsible for the remaining out-of-pocket costs for PADCEV. The Program is not valid for patients insured by any state or federal healthcare program, including, but not limited to, Medicaid, Medicare, Medigap, Department of Defense (DoD), Veterans Affairs (VA), TRICARE, Puerto Rico Government Insurance, or any state patient or pharmaceutical assistance program. Patients who move from commercial insurance to federal or state prescription health insurance will no longer be eligible, and agree to notify the Program of any such change. This offer is not valid for cash paying patients. Patients agree not to seek reimbursement from any health insurance or third party for all or any part of the benefit received by the patient through the Program. This offer is not conditioned on any past, present, or future purchase of PADCEV. This offer is not transferrable, has no cash value, and cannot be combined with any other offer, free trial, prescription savings card, or discount. The full value of the Program benefits is intended to pass entirely to the eligible patient. The benefit available under this Program is valid only for the patient's out-of-pocket medication costs for PADCEV. The benefit is not valid for any other out-of-pocket costs such as medication administration charges or other healthcare provider services. No other individual or entity (including, without limitation, third party payers, pharmacy benefit managers, or the agents of either) is entitled to receive any benefit, discount, or other amount in connection with this Program. This offer is not health insurance and is only valid for patients in the 50 United States, Washington DC, and Puerto Rico. This Program is void where prohibited by law. No membership fees. Certain rules and restrictions apply. Astellas reserves the right to revoke, rescind, or amend this offer without notice for any reason (including to ensure that the offer is utilized solely for the patient's benefit).

 

gProgram is subject to eligibility criteria. Terms and conditions apply. Void where prohibited by law.

 

hSupport is provided through third-party organizations that operate independently and are not controlled or endorsed by Astellas or Pfizer. Availability of support and eligibility requirements are determined by these organizations.

References: 1. Centers for Medicare and Medicaid Services. July 2025 alpha-numeric HCPCS file. Updated July 9, 2025. Accessed August 7, 2025. https://www.cms.gov/medicare/coding-billing/healthcare-common-procedure-system/quarterly-update 2. PADCEV [package insert]. Northbrook, IL: Astellas Pharma US, Inc. 3. American Medical Association. CPT® 2024 Professional Edition. American Medical Association, 2023. 4. Centers for Medicare and Medicaid Services. ICD-10-CM tabular list of diseases and injuries. Updated August 7, 2025. Accessed August 14, 2025. https://www.cms.gov/medicare/coding-billing/icd-10-codes