Support for Your CRESEMBA Patients

CRESEMBA Support SolutionsSM, a component of Astellas Pharma Support SolutionsSM, offers access and reimbursement support to help patients address potential challenges accessing CRESEMBA® (isavuconazonium sulfate) capsules.

 

CRESEMBA Support Solutions provides information regarding patient healthcare coverage options and financial assistance options that may be available to help patients with financial needs.

 

To speak with a dedicated access specialist, please call us at 1-800-477-6472, Monday–Friday, 8:00 AM–8:00 PM ET.

After the patient has been prescribed CRESEMBA, the patient can be enrolled in CRESEMBA Support Solutions.a

To Enroll Your Patient 

Complete the enrollment form online by going to  CRESEMBAaccess.com, or print out the Patient Enrollment Form and fax the completed form to 1-866-317-6235. Be sure to include all healthcare provider and patient signatures.

The CRESEMBA Support Solutions Checklist provides information on the enrollment process.

CRESEMBA Support Solutionsa offers benefits verification assistance to evaluate a patient's insurance coverageb for CRESEMBA. After performing a benefits verification, we will provide a Summary of Benefits that includes:

 

  • The patient's insurance coverage requirements for CRESEMBA
  • Requirements for prior authorization, step edit, or other coverage restrictions, if any
  • Cost-sharing responsibility, including deductibles, coinsurance or copayment, and out-of-pocket maximums

The Process 

Step 1: Upon completion of the patient enrollment process, CRESEMBA Support Solutions will begin the benefits verification process. 

Step 2: Once benefits verification is complete, we will send a Summary of Benefits. 

CRESEMBA Support Solutionsa will provide prior authorization (PA) assistance when a healthcare provider makes a direct request for assistance with a PA, if required.

The Process 

  1. Upon completion of the patient enrollment process, CRESEMBA Support Solutions will verify insurance coverage and obtain the appropriate PA form.
  2. CRESEMBA Support Solutions will provide a Summary of Benefits that includes PA requirements. Additionally, we will transfer information provided on the Patient Enrollment Form to prepopulate the PA form solely with basic patient and healthcare provider information.
  3. The healthcare provider must then review, complete, and submit the PA form to the payer.c

Prior Authorization Denial Appeals

If the patient's insurance denies a PA request, CRESEMBA Support Solutions can assist with the appeal process for a denied PA request.

  1. CRESEMBA Support Solutions will determine if any additional documentation is required by the patient's insurer.
  2. CRESEMBA Support Solutions will inform the healthcare provider of what information is needed and how to provide it to the insurer.c
  3. The healthcare provider completes and submits the appeal to the insurer.
  4. CRESEMBA Support Solutions will track and inform the healthcare provider of the appeal status.

Relevant Billing Codes for CRESEMBA

Properly coding claims can help facilitate timely claims processing and reduce the risk of denied claims. Coverage, coding, and reimbursement policies vary by payer, patient, and setting of care. Healthcare providers should verify coverage, coding, and reimbursement guidelines on a case-by-case basis.

The coding systems in the following tables can assist you in proper coding for CRESEMBAd:

Universal 10-digit product identifier for human drugs; each NDC identifies the labeler, product, and trade package size

Formulation NDC Code Code Description
Oral 0469-0520-02 14-count carton (contains two individual aluminum blister packs of 7 capsules per sheet with desiccant)
Oral 0469-2860-35 35-count carton (contains seven individual aluminum blister packs of 5 capsules per sheet with desiccant)
IV 0469-0420-01 Individually packaged single-dose vial

Alphanumeric classification descriptive of diseases, injuries, and causes of death 

Code Code Description
B44.0 Invasive pulmonary aspergillosis
B44.1 Other pulmonary aspergillosis
B44.2 Tonsillar aspergillosis
B44.7 Disseminated aspergillosis
B44.81 Allergic bronchopulmonary aspergillosis
B44.89 Other forms of aspergillosis
B44.9 Aspergillosis, unspecified
B46.0 Pulmonary mucormycosis
B46.1 Rhinocerebral mucormycosis
B46.2 Gastrointestinal mucormycosis
B46.3 Cutaneous mucormycosis
B46.4 Disseminated mucormycosis
B46.5 Mucormycosis, unspecified
B46.8 Other zygomycoses
B46.9 Zygomycosis, unspecified

4-digit codes that all hospitals use to capture cost data by department

Code Code Description
0250 Pharmacy-General
0260 Intravenous Therapy-General
0636 Pharmacy-Extension (drugs requiring detailed coding)
Notes
Some payers, such as Medicare, require certain combinations of revenue codes and Healthcare Common Procedure Coding System (HCPCS) or CPT®e codes to facilitate claims processing in the Hospital Outpatient Department (HOPD) setting. Confirm requirements with local payer policies.

5-digit alphanumeric code 

Code Code Description
J1833 Injection, isavuconazonium, 1 mg

Patient Assistance

CRESEMBA Support Solutionsa is committed to identifying potential financial assistance options to assist patients with their out-of-pocket expenses.

The CRESEMBA QUICK START+ Program provides a one-time, 7-day supply of CRESEMBA at no cost to eligible new patients who experience an insurance-related delay.

To be eligible for the QUICK START+ Program, patients must: 

  • Have prescription drug insurance 
  • Be new to CRESEMBA therapy 
  • Have experienced an insurance-related access delay 
  • Have been prescribed CRESEMBA for an FDA-approved indication

Offers overnight shipping directly to the patient.f

The CRESEMBA Patient Savings Programg is for eligible patients who have commercial prescription insurance. Under this program:

  • A patient must have a valid prescription, meet the eligibility requirements, and present the Savings Card to their pharmacist 
  • Patients may pay as little as $25 per prescription 
  • Annual maximum copay assistance limit of $4,000 per calendar year 
  • There are no income requirements 

Obtaining the Savings Card

The patient must present the Savings Card to the pharmacy when they fill their prescription. There are 2 ways for the patient to receive the Savings Card:

Contact CRESEMBA Support Solutionsa at 1-800-477-6472 to learn more or determine whether your patient is eligible for enrollment in the CRESEMBA Patient Savings Program. 

The Astellas Patient Assistance Programh provides CRESEMBA at no cost to patients who meet the program eligibility requirements.

Eligibility Requirements

CRESEMBA Support Solutionsa can assess whether the patient meets the eligibility requirements.

The patient may be eligible if they: 

  • Are uninsured; a patient is considered uninsured when a patient has no prescription drug insurance
  • Have a verifiable shipping address in the United States 
  • Have been prescribed CRESEMBA for an FDA-approved indication 
  • Meet the program financial eligibility requirements 

Application Process

Upon completion of the Patient Enrollment Process, we will evaluate and determine if the patient is eligible for this program. If the patient is eligible, we will notify you and the patient and then ship the patient's CRESEMBA medication directly to their home.

For more information, call 1-800-477-6472, Monday–Friday, 8:00 AM–8:00 PM ET. 

aCRESEMBA Support Solutions is a component of Astellas Pharma Support SolutionsSM.

bAstellas does not guarantee third-party coverage, payment, or reimbursement for claims. Coverage and reimbursement vary by payer, patient, and setting of care and are subject to change. Therefore, it is important that providers verify each patient's insurance coverage prior to initiating therapy. Each healthcare provider is ultimately responsible for determining coverage for individual patients.

cThe healthcare provider remains responsible for populating all clinical information.

dIMPORTANT INFORMATION: The coding, coverage, and payment information contained herein is gathered from various resources, general in nature, and subject to change without notice. Third-party payment for medical products and services is affected by numerous factors. It is always the provider's responsibility to determine the appropriate healthcare setting and to submit true and correct claims conforming to the requirements of the relevant payer for those products and services rendered. Pharmacies and providers submitting a claim should contact third-party payers for specific information on their coding, coverage, and payment policies. Information and materials provided by CRESEMBA Support Solutions are to assist pharmacies and other providers submitting a claim, but the responsibility to determine coverage, reimbursement, and appropriate coding for a particular patient and/or procedure remains at all times with the pharmacy and provider that submits the claim. Information provided by CRESEMBA Support Solutions or Astellas should in no way be considered a guarantee of coverage or reimbursement for any product or service.

eAmerican Medical Association. Current Procedural Terminology® (CPT®). Professional edition, 2023. All rights reserved. Applicable FARS/DFARS Restrictions Apply to Government Use. Fee schedules, relative value units, conversion factors and/or related components are not assigned by the AMA, are not part of CPT®, and the AMA is not recommending their use. The AMA does not directly or indirectly practice medicine or dispense medical services. The AMA assumes no liability for data contained or not contained herein.

fProvided request is submitted by 2:00 PM ET.

gBy enrolling in the CRESEMBA Patient Savings Program ("Program"), the patient or the patient’s legal representative (e.g., parent or legal guardian) acting on behalf of the patient, attests that the patient currently meets the eligibility criteria and will comply with the following terms and conditions: The Program is for eligible patients with commercial prescription insurance and is good for use only with a valid prescription for CRESEMBA at the time the prescription is dispensed by the pharmacy. The Program has a maximum copay assistance limit of $4,000 per calendar year. After the annual maximum copay assistance is reached, patient will be responsible for the remaining monthly out-of-pocket costs for CRESEMBA. The Program is not valid for patients whose prescription claims are reimbursed, in whole or in part, by any state or federal government program, including, but not limited to, Medicaid, Medicare, Medigap, Department of Defense (DoD), Veterans Affairs (VA), TRICARE, or any state patient or pharmaceutical assistance program. Patients who move from commercial insurance to federal or state prescription health insurance will no longer be eligible, and agree to notify the Program of any such change. Patients agree not to seek reimbursement from any health insurance or third party for any part of the benefit received by the patient through the Program. This offer is not conditioned on any past, present, or future purchase of CRESEMBA. This offer is not transferrable, has no cash value, and cannot be combined with any other offer, free trial, prescription savings card, or discount (including any program offered by a third party payer or pharmacy benefit manager, or an agent of either, that adjusts patient cost-sharing obligations, through arrangements that may be referred to as "accumulator" or "maximizer" programs). The full value of the Program benefits is intended to pass entirely to the eligible patient. No other individual or entity (including, without limitation, third party payers, pharmacy benefit managers, or the agents of either) is entitled to receive any benefit, discount or other amount in connection with this Program. This offer is not health insurance and is only valid for patients in the 50 United States and Washington DC. This offer is not valid for cash paying patients. This Program is void where prohibited by law. No membership fees. It is illegal to sell, purchase, trade, counterfeit, duplicate, or reproduce, or offer to sell, purchase, trade, counterfeit, duplicate or reproduce the card. This offer will be accepted only at participating pharmacies. Certain rules and restrictions apply. Astellas reserves the right to revoke, rescind, or amend this offer without notice for any reason (including to ensure that the offer is utilized solely for the patient's benefit).

hSubject to eligibility criteria. Terms and conditions apply. The program is void where prohibited by law.

References: 1. CRESEMBA [package insert]. Northbrook, IL: Astellas Pharma US, Inc. 2. Centers for Medicare and Medicaid Services. ICD-10-CM tabular list of diseases and injuries. Updated August 7, 2025. Accessed August 14, 2025. https://www.cms.gov/medicare/coding-billing/icd-10-codes 3. Noridian Healthcare Solutions. Jurisdiction E - Medicare Part A: revenue codes. Updated June 17, 2025. Accessed August 7, 2025. https://med.noridianmedicare.com/web/jea/topics/claim-submission/revenue-codes 4. Centers for Medicare and Medicaid Services. July 2025 alpha-numeric HCPCS file. Updated July 9, 2025. Accessed August 7, 2025. https://www.cms.gov/medicare/coding-billing/healthcare-common-procedure-system/quarterly-update

QUICK START+® and CRESEMBA® are registered trademarks of Astellas US LLC.